Lamotrigine
نویسندگان
چکیده
منابع مشابه
Teratogenicity of lamotrigine.
QUESTION One of my female patients has epilepsy and is currently receiving lamotrigine monotherapy. She has recently found that she is 6 weeks pregnant and is concerned about possible side effects of lamotrigine on her fetus. How should I advise her and should I switch to another antiepileptic drug? ANSWER Lamotrigine (LTG) has not been associated with an increased risk for major malformation...
متن کاملLamotrigine after corpus callosotomy
Corpus callosotomy (CC) has been employed in the management of intractable epilepsy since 1940’ and should be considered for patients with generalized falling seizures with physical injury, recurrent life-threatening generalized convulsive status epilepticus or atypical absence status’. CC is especially useful in improving seizure control in patients with tonic and atonic seizures3 and those wi...
متن کاملLamotrigine therapeutic thresholds
PURPOSE To evaluate therapeutic drug monitoring (TDM) of lamotrigine (LTG) with establishment of individual therapeutic thresholds (TT) in outpatients of a tertiary epilepsy centre on monotherapy. METHODS In the outpatient clinic of the Danish Epilepsy Centre, Dianalund, all patients treated in 2004 with LTG monotherapy were identified. Patients who had not reported seizures or adverse reacti...
متن کاملLamotrigine and catamenial epilepsy
Catamenial epilepsy (CE) is characterized by epileptic seizures in the female occurring rhythmatically with the menstrual cycle. Hormonal mechanisms have been proposed as a cause of this epileptic form. Few reports about the efficacy of anti-epileptic drugs (AEDs) have been published. We studied prospectively women with CE who were treated with lamotrigine (LTG) for a period of 3 months in orde...
متن کاملPossible bioactivation pathways of lamotrigine.
The anticonvulsant lamotrigine is associated with idiosyncratic drug reactions, especially skin rashes. Most idiosyncratic reactions are believed to be caused by reactive metabolites. Previous studies have found evidence that an arene oxide is formed in rats; however, when we incubated radiolabeled lamotrigine with rat liver microsomes virtually no covalent binding was detected, and the expecte...
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ژورنال
عنوان ژورنال: Reactions Weekly
سال: 2021
ISSN: ['1179-2051', '0114-9954']
DOI: https://doi.org/10.1007/s40278-021-95130-5